Tomoaki Ikeda Selected Research

Fetal Growth Retardation (Intrauterine Growth Retardation)

12/2022	Assessment of the value of measuring soluble fms-like tyrosine kinase-1 and placental growth factor levels following administration of tadalafil to treat fetal growth restriction.
1/2022	Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling.
1/2022	Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb).
11/2021	Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial.
4/2021	Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy.
1/2021	Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.
12/2020	Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction.
5/2020	Developmental Evaluation of Infants Who Have Received Tadalafil in Utero for Fetal Growth Restriction.
1/2020	Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
10/2019	Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy.

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Tomoaki Ikeda Research Topics

Disease

23	Fetal Growth Retardation (Intrauterine Growth Retardation) 12/2022 - 01/2012
22	Hypoxia (Hypoxemia) 12/2020 - 08/2002
11	Pre-Eclampsia (Preeclampsia) 01/2022 - 05/2014
11	Hemorrhage 01/2022 - 02/2005
11	Ischemia 01/2021 - 08/2002
10	Brain Injuries (Brain Injury) 12/2018 - 08/2002
7	Neoplasms (Cancer) 08/2021 - 09/2012
7	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2016 - 08/2002
6	Infections 01/2022 - 03/2005
6	Inflammation (Inflammations) 01/2022 - 04/2004
6	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/2021 - 01/2020
6	Cardiovascular Diseases (Cardiovascular Disease) 08/2019 - 01/2012
5	Birth Weight (Birth Weights) 06/2022 - 06/2014
5	Cerebral Palsy (Spastic Diplegia) 01/2022 - 01/2004
5	Cardiac Arrhythmias (Arrythmia) 08/2019 - 08/2017
5	Amniotic Fluid Embolism 10/2018 - 01/2011
4	Spontaneous Abortion (Miscarriage) 12/2020 - 02/2007
4	Tachycardia (Tachyarrhythmias) 11/2020 - 01/2013
4	Maternal Death 05/2020 - 01/2011
4	Uterine Rupture 03/2020 - 01/2016
4	Fetal Death 03/2019 - 02/2007
4	Cerebral Infarction 09/2009 - 08/2002
3	COVID-19 09/2022 - 09/2021
3	Hypothermia 07/2022 - 05/2004
3	Headache (Headaches) 11/2021 - 06/2019
3	Endometrial Neoplasms (Endometrial Cancer) 08/2021 - 03/2014
3	Heart Failure 04/2021 - 01/2018
3	HELLP Syndrome 05/2020 - 05/2014
3	Anemia 02/2019 - 01/2018
3	Congenital Heart Defects (Congenital Heart Defect) 01/2019 - 01/2018
3	Premature Birth (Birth, Premature) 01/2018 - 07/2017
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 09/2017 - 03/2013
3	Stroke (Strokes) 01/2016 - 01/2015
2	Neoplasm Metastasis (Metastasis) 11/2021 - 07/2013
2	Cytomegalovirus Infections (Inclusion Disease) 10/2021 - 07/2021
2	Fetal Weight 04/2021 - 09/2019
2	Polyhydramnios 01/2021 - 01/2019
2	Abruptio Placentae (Placental Abruption) 01/2021 - 01/2016
2	Insulin Resistance 03/2020 - 08/2015
2	Fibrosis (Cirrhosis) 01/2020 - 10/2013
2	Hypertension (High Blood Pressure) 01/2020 - 06/2017
2	Infant Death 01/2020 - 06/2019
2	Perinatal Death 06/2019 - 04/2019
2	Dyspnea (Shortness of Breath) 03/2019 - 11/2013
2	Hydrops Fetalis (Fetal Edema) 01/2019 - 08/2017
2	Thrombosis (Thrombus) 09/2017 - 09/2015

Drug/Important Bio-Agent (IBA)

21	Tadalafil (Cialis)FDA Link 12/2022 - 11/2016
7	Oxygen (Dioxygen)IBA 09/2021 - 10/2002
5	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2022 - 12/2017
5	Pharmaceutical PreparationsIBA 04/2021 - 03/2005
5	LipopolysaccharidesIBA 06/2007 - 04/2004
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2022 - 01/2019
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2018
4	Phosphodiesterase 5 InhibitorsIBA 11/2021 - 12/2017
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 08/2015
4	Natriuretic PeptidesIBA 01/2020 - 01/2018
4	Fibrinogen (Factor I)FDA Link 03/2019 - 01/2017
4	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2015 - 03/2005
4	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 07/2011 - 11/2002
4	EdaravoneIBA 02/2007 - 08/2002
3	Dexamethasone (Maxidex)FDA LinkGeneric 12/2020 - 03/2005
3	EnzymesIBA 05/2020 - 05/2014
3	Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)IBA 10/2018 - 06/2014
3	AntithrombinsIBA 03/2017 - 09/2015
3	Protein SIBA 03/2017 - 08/2011
3	Therapeutic UsesIBA 01/2016 - 11/2010
3	CannabidiolIBA 09/2009 - 10/2004
2	Tyrosine (L-Tyrosine)FDA Link 12/2022 - 01/2022
2	Hemostatics (Antihemorrhagics)IBA 01/2022 - 09/2015
2	AntibodiesIBA 10/2021 - 12/2018
2	AntigensIBA 03/2021 - 09/2015
2	Proteins (Proteins, Gene)FDA Link 12/2020 - 03/2017
2	Propranolol (Inderal)FDA LinkGeneric 11/2020 - 12/2008
2	Adrenergic Agents (Adrenergic Drugs)IBA 11/2020 - 01/2020
2	CatecholaminesIBA 11/2020 - 01/2020
2	Progesterone FDA LinkGeneric 10/2020 - 01/2012
2	Hormones (Hormone)IBA 10/2020 - 01/2019
2	CytokinesIBA 08/2020 - 01/2019
2	BilirubinIBA 05/2020 - 01/2019
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2020 - 11/2016
2	Heparin (Liquaemin)FDA LinkGeneric 03/2019 - 01/2019
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2019 - 01/2012

Therapy/Procedure

23	Therapeutics 09/2022 - 03/2005
15	Cesarean Section (Caesarean Section) 03/2022 - 02/2005
8	Hysterectomy 01/2022 - 02/2005
6	Lymph Node Excision (Lymph Node Dissection) 08/2021 - 09/2013
5	Transplantation 01/2014 - 11/2010
4	Ligation 11/2004 - 12/2002
3	Neoadjuvant Therapy 06/2022 - 11/2016
3	Epidural Anesthesia 03/2022 - 01/2016
3	Drug Therapy (Chemotherapy) 08/2021 - 12/2018
3	Laparotomy 08/2021 - 09/2012
3	Catheters 01/2013 - 01/2012
2	Anesthesia 03/2022 - 10/2020
2	Perinatal Care 01/2022 - 09/2020
2	Critical Care (Surgical Intensive Care) 06/2021 - 03/2021
2	Oral Administration 04/2021 - 01/2021
2	Trachelectomy 01/2021 - 01/2020
2	Radiotherapy 01/2021 - 11/2016
2	Uterine Myomectomy 04/2019 - 01/2016